2-(5-Bromopentyl)-4-chloro-5-[2-(4-methoxyphenyl)ethylamino]pyridazin-3(2H)-one
نویسندگان
چکیده
The asymmetric unit of the title compound, C(18)H(23)BrClN(3)O(2), consists of two mol-ecules which exhibit different conformations of the pentyl chains [C-C-C-C torsion angles of -60.4 (4) and 175.8 (3)°]. The crysal packing exhibits a chain structure, generated through the O atom of the pyridazinone forming a hydrogen bond with the N-H group of an adjacent mol-ecule.
منابع مشابه
2-Substituted 4-, 5-, and 6-[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones and 2-substituted 4,5-bis[(1E)-3-oxo-3-phenylprop-1-en-1-yl]pyridazin-3(2H)-ones as potent platelet aggregation inhibitors: design, synthesis, and SAR studies.
A set of regioisomeric 2-substituted pyridazin-3(2H)-ones containing a 3-oxo-3-phenylprop-1-en-1-yl fragment at either position 4, 5 or 6 and 2-substituted pyridazin-3(2H)-ones containing the same fragment both at positions 4 and 5 have been synthesized and evaluated as antiplatelet agents. The study allows the identification of a new highly potent platelet aggregation inhibitor (4c).
متن کامل2-tert-Butyl-4-chloro-5-[4-(2-fluoroethoxy)benzyloxy]pyridazin-3(2H)-one
In the title compound, C(17)H(20)ClFN(2)O(3), the dihedral angle between the pyridazine and benzene rings is 41.37 (10)°. In the crystal, there are no significant intermolecular interactions present. The terminal -CH(2)F group is disordered over two sets of sites with an occupancy ratio of 0.737 (2):0.263 (2).
متن کاملBacterial hydroxylation of pyrazon compounds.
Abbreviations: Pyrazon, 5-amino-4-chloro-2-phenyl-3 (2H) pyridazinone; o-methyl-pyrazon, 5-amino-4-chloro-2(2-methylphenyl)-3(2H)-pyridazinone; m-methyl-pyrazon, 5-aminoj4-chloro-2(3-methylphenyl) 43 (2H) -pyridazinone; p-methyl-pyrazon, 5-amino-4-chloro-2(4-methylphenyl) -3 (2H) pyridazinone. Requests for reprints should be sent to Prof. Dr. F. Lingens, Institut für Mikrobiologie und Molekular...
متن کاملMethyl carbonium ion migration during the reaction of 4-chloro-5-methoxyl-3(2H)-pyridazinone with trifluoroethylation agents.
To synthesize 4-chloro-5-methoxy-2-(b-trifluoroethyl)-3(2H)-pyridazinone (4), the reactions of 4-chloro-5-methoxy-3(2H)-pyridazinone (5) with RCH(2)CF(3)(R = I, TsO, MsO, TfO) in different solvents were studied. It was found that methyl group migration took place during this reaction. An oxonium salt 9 was suggested as the active intermediate for the formation of the byproduct 4-chloro-5-methox...
متن کاملCrystal structure of 4-chloro-2-[(5-ethoxy-1,3,4-thiadiazol-2-yl)methyl]-5-(piperidin-1-yl)pyridazin-3(2H)-one
In the title mol-ecule, C14H18ClN5O2S, the six atoms of the 1,6-di-hydro-pyridazine ring are essentially coplanar (r.m.s. deviation = 0.008 Å), and the dihedral angle between this and the 1,3,4-thia-diazole ring is 62.06 (10)°. In the crystal, centrosymmetrically related mol-ecules are linked by inter-molecular C-H-O hydrogen bonding to form a supra-molecular dimer. The terminal ethyl group is ...
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عنوان ژورنال:
دوره 66 شماره
صفحات -
تاریخ انتشار 2010